ICARE Social Media Post October 2025

BRCA1/2, PALB2, CHEK2, & ATM: How does family history of breast cancers affect risk?

In a new study of almost 70,000 women, including those with hereditary forms of breast cancer, breast cancer risk was higher in those with a family history of breast cancer.

Family history raised breast cancer risks:

  • The least in BRCA1 carriers (see panel 3)
  • The most in PALB2 carriers (see panel 6)

✨Why is this important? ✨
This type of information to personalize risk estimates can help women to guide screening and prevention decisions

To learn more read the article at: https://jamanetwork.com/journals/jamaoncology/article-abstract/2839917

Reference: O’Brien, et al. JAMA Oncology. Published online October 09, 2025. doi:10.1001/jamaoncol.2025.3875. PMID: 41066089.

Permanent link to this article: https://inheritedcancer.net/post10282025/