A new study indicated treatment with pembrolizumab (Ketruda) resulted in benefit in patients with MSI-H advanced uterine cancer. Read the full article to learn more!https://ascopubs.org/doi/10.1200/JCO.21.01874Reference: O’Malley et al. J Clin Oncol. 2022 Jan 6;JCO2101874. PMID: 34990208.
Care Consideration: PD-1 Inhibitors
Permanent link to this article: https://inheritedcancer.net/post30122/
ICARE Social Media Post January 2020
Advances in Treatment for Lynch Syndrome-Related Endometrial Cancer
ICARE Social Media Post January 2020
Advances in Treatment for Lynch Syndrome-Related Endometrial Cancer
A recent phase II study showed increased response to an immunotherapy drug (avelumab), in women with endometrial cancer with mismatch repair deficiency. Among women with Lynch Syndrome, the risk for endometrial cancer (which often has mismatch repair deficiency) is raised. This new study shows promising treatment options for women with endometrial cancer and Lynch syndrome …
Permanent link to this article: https://inheritedcancer.net/13020/
ICARE Newsletter Winter 2018
Advances in New Treatments for Individuals with Lynch Syndrome
ICARE Newsletter Winter 2018
Advances in New Treatments for Individuals with Lynch Syndrome
A recently published phase II clinical trial investigated the use of a new class of drugs (called PD-1 Inhibitors) in DNA mismatch repair-deficient/ microsatellite instability-high colorectal tumors (which are features seen in the majority of colorectal tumors from individuals with Lynch Syndrome) among patients with metastatic disease.1 Investigators found patients who received two PD-1 Inhibitors …
Permanent link to this article: https://inheritedcancer.net/7nlw2018/
ICARE Newsletter Summer 2017
Emerging FDA Approvals of Immunotherapy Among Patients With Metastatic MSI-H Cancers
ICARE Newsletter Summer 2017
Emerging FDA Approvals of Immunotherapy Among Patients With Metastatic MSI-H Cancers
Over the last few years, immunotherapy has emerged as an exciting new class of drugs. As early as 2015, immunotherapy through PD-1 Inhibitors among patients with MSI-H colorectal cancers was shown to be of potential benefit.1 As many individuals with Lynch Syndrome have cancers that are MSI-H and mismatch repair deficient, this class of drugs …
Permanent link to this article: https://inheritedcancer.net/5nls2017/
ICARE Newsletter Winter 2017
The Potential Promise of Immunotherapy Targeted to Those with Bi-Allelic Mutations in Lynch Syndrome Genes
ICARE Newsletter Winter 2017
The Potential Promise of Immunotherapy Targeted to Those with Bi-Allelic Mutations in Lynch Syndrome Genes
People with Lynch Syndrome have a non-working Lynch gene (“mutation”), while the other copy of that gene is normal (recognizing that all of these genes come in pairs, with one member of the pair coming from each parent). Over the last few years, there has been an increased realization that some individuals have a mutation …
Permanent link to this article: https://inheritedcancer.net/2nlw2017/
ICARE Newsletter Summer 2015
Advances in Preventive and Treatment Approaches for Individuals with Lynch Syndrome
ICARE Newsletter Summer 2015
Advances in Preventive and Treatment Approaches for Individuals with Lynch Syndrome
A study of over 1800 individuals with a mutation in one of the Lynch Syndrome genes was recently completed to assess whether aspirin and ibuprofen use may reduce colon cancer risk. Results showed that in those who took aspirin or ibuprofen for between 1 month and 4.9 years, the colon cancer risks were lower than …
Permanent link to this article: https://inheritedcancer.net/6nls2015/