The question was addressed by Brian Shirts, MD, PhD, President of ConnectMyVariant and Service Medical Director of the Molecular Genetics Laboratories at Vanderbilt University Medical Center. If you have a question you would like addressed, email ICARE@vumc.org for consideration in future newsletters. Q: Why do you think cascade testing has not happened as much as …
Permanent link to this article: https://inheritedcancer.net/nlf202511/
Cascade testing refers to testing family members for a gene mutation after another family member is found to have a mutation. Once family members get cascade testing, they can also benefit from screening, cancer prevention, and early detection strategies. A study conducted a microsimulation model to look at the cost effectiveness of cascade testing of …
Permanent link to this article: https://inheritedcancer.net/nlf20258/
Cascade testing refers to testing “at-risk” family members for a gene mutation, once the mutation has been found in a family member. For Lynch syndrome, once family members get cascade testing, they can also benefit from screening, cancer prevention, and early detection strategies. Findings of a microsimulation model looking at the cost effectiveness of cascade …
Permanent link to this article: https://inheritedcancer.net/post061025/
Check out a recent article led by the ICARE team, published in the Journal of Genetic Counseling, outlining family communication of genetic test results among female BRCA1/2, PALB2, CHEK2, and ATM carriers. Check out the full article at: https://onlinelibrary.wiley.com/doi/full/10.1002/jgc4.1356
Permanent link to this article: https://inheritedcancer.net/post40221/
We are excited to tell you about our recently published results based solely on data from ICARE participants with ATM and CHEK2 mutations. Our findings suggest most female family members of ATM and CHEK2 mutation carriers do not qualify for breast MRI screening based on family cancer history alone. This emphasizes the need to share …
Permanent link to this article: https://inheritedcancer.net/icare-newsletter-winter-2020new-study-based-on-icare-participants-with-atm-chek2-mutations/
Once an individual has had genetic testing for inherited cancer predisposition this information could help their close family members. For example, when a BRCA mutation or a mutation in another inherited cancer gene is found, it is important for close family members (with or without a diagnosis of cancer) to know so they too can …
Permanent link to this article: https://inheritedcancer.net/1nlw2016/
