PREMM5 is a model to estimate the risk for having Lynch Syndrome. PREMMplus is a model that estimates risks in 19-cancer risk genes, including Lynch Syndrome genes, BRCA, and other genes. A new study that compared PREMM5 and PREMMplus found that PREMMplus was just as good as PREMM5 in identifying patients with Lynch Syndrome. PREMMplus …
Permanent link to this article: https://inheritedcancer.net/post060325/
A new study among patients with Familial Adenomatous Polyposis (FAP), most of whom had a their colon removed to prevent cancer, found that although risk-reducing colectomy is now standard practice in FAP patients, colorectal cancer remains the most common cancer and cause of death in these patients. Recognizing cases of FAP that are ‘de novo’ …
Permanent link to this article: https://inheritedcancer.net/post52725/
Lynch syndrome related cancers have a distinct immune profile. They are generally “immunogenic”, meaning there might be opportunities to develop immune-interception strategies to prevent cancer. What is cancer “interception”? A new study based on work in mice showed that an EZH2 inhibitor (called GSK503) given over 9 weeks in mice lowered the number of adenomas …
Permanent link to this article: https://inheritedcancer.net/post50525/
