A new study found that compared to those with BRCA2 mutations outside exon 11, those with exon 11 mutations had a lower breast cancer risk, higher risk for ER-negative breast cancer, and later age at diagnosis. These findings suggest that taking mutation type and location into account in cancer risk models may improve the ability …
Tag: Cancer Risk
Permanent link to this article: https://inheritedcancer.net/nlf20255/
ICARE Newsletter Fall 2025
BRCA1/2 Carriers: High Risk of Breast Implant-Associated Lymphoma
ICARE Newsletter Fall 2025
BRCA1/2 Carriers: High Risk of Breast Implant-Associated Lymphoma
In a new study of female BRCA1/2 carriers who had breast cancer, there was a 16-fold higher risk of anaplastic large-cell lymphoma associated with breast implants. This occurred in BRCA1/2 carriers who received textured breast implants as part of breast reconstruction. This is important information for BRCA1/2 carriers to know about to guide breast reconstruction …
Permanent link to this article: https://inheritedcancer.net/nlf20254/
ICARE Newsletter Fall 2025
BRIP1: Third Most Common Gene for Inherited Ovarian Cancer
ICARE Newsletter Fall 2025
BRIP1: Third Most Common Gene for Inherited Ovarian Cancer
In a new study of unselected women with ovarian cancer, BRIP1 was the third most common gene for inherited ovarian cancer at a frequency of 1.1%, following BRCA1/2 which were found in 14.8%. Other inherited ovarian cancer genes included PALB2 (0.8%), RAD51C (0.4%), and RAD51D (0.4%). Beyond BRCA1/2 testing, additional testing through inherited cancer multi-gene …
Permanent link to this article: https://inheritedcancer.net/nlf20256/
ICARE Newsletter Fall 2025
BRCA1/2 Carriers with Breast Cancer: Removal of Ovaries and Fallopian Tubes Lowers Risk of Death
ICARE Newsletter Fall 2025
BRCA1/2 Carriers with Breast Cancer: Removal of Ovaries and Fallopian Tubes Lowers Risk of Death
A new study among BRCA1/2 carriers with breast cancer showed that the overall risk of death was 48% lower for those that removed their ovaries and fallopian tubes. Specifically, these women had lower risks of all-cause mortality, breast cancer-specific mortality, and second non-breast cancer development. Removing the ovaries leads to menopause which has other health …
Permanent link to this article: https://inheritedcancer.net/nlf20252/
ICARE Newsletter Fall 2025
Ovarian Cancer: 1 in 4 Cases Could Have Been Prevented!
ICARE Newsletter Fall 2025
Ovarian Cancer: 1 in 4 Cases Could Have Been Prevented!
A new study of 1877 ovarian cancer patients showed almost 25% of patients had ‘missed opportunities’ for salpingectomy (removal of fallopian tubes) when they had another surgery or procedure before their ovarian cancer diagnosis. Additionally, 6% of patients had a close relative with ovarian cancer, and almost 20% had a mutation in an ovarian cancer …
Permanent link to this article: https://inheritedcancer.net/nlf20253/
ICARE Newsletter Fall 2025
Lynch Syndrome: Showing the Importance of Family Testing
ICARE Newsletter Fall 2025
Lynch Syndrome: Showing the Importance of Family Testing
Cascade testing refers to testing family members for a gene mutation after another family member is found to have a mutation. Once family members get cascade testing, they can also benefit from screening, cancer prevention, and early detection strategies. A study conducted a microsimulation model to look at the cost effectiveness of cascade testing of …
Permanent link to this article: https://inheritedcancer.net/nlf20258/
ICARE Newsletter Fall 2025
ICARE Community Spotlight: Kathy Baker
ICARE Newsletter Fall 2025
ICARE Community Spotlight: Kathy Baker
I was only 30 when my 32-year-old sister was diagnosed with breast cancer. A couple years later, when a mobile mammography bus showed up at my law school offering free mammograms, I decided it couldn’t hurt to be screened. When my mammogram was normal, I made plans to wait until age 50 for my next …
Permanent link to this article: https://inheritedcancer.net/nlf202512/
ICARE Social Media Post August 2025
Lynch Syndrome: Low Dose Aspirin Lowers Colorectal Cancer Risk
ICARE Social Media Post August 2025
Lynch Syndrome: Low Dose Aspirin Lowers Colorectal Cancer Risk
According to new results of the Colorectal Adenoma/Carcinoma Prevention Program 3 (CaPP3) study presented at the International Cancer Prevention Conference in London, low-dose aspirin (100 mg) lowered the risk of colorectal cancer in patients with Lynch syndrome. Additionally, the use of aspirin lowered the risk of all cancers associated with Lynch syndrome. Learn more by …
Permanent link to this article: https://inheritedcancer.net/post081225/
ICARE Social Media Post August 2025
NCCN CEG Guidelines (V1.2025): CDH1 Post
ICARE Social Media Post August 2025
NCCN CEG Guidelines (V1.2025): CDH1 Post
The National Comprehensive Cancer Network (NCCN) released updated Genetic/Familial High-Risk Assessment: Colorectal, Endometrial, Gastric Cancer guidelines on June 13th, 2025 (Version 1.2025). Included in these new guidelines are updates to the CDH1 content as outlined below: HGAST-A (Page 97) HGAST-A (Page 97) To read more, check out the full guidelines by creating a FREE account …
Permanent link to this article: https://inheritedcancer.net/post081125/
ICARE Social Media Post August 2025
NCCN BOPP Guidelines (V1.2026): CHEK2
ICARE Social Media Post August 2025
NCCN BOPP Guidelines (V1.2026): CHEK2
The National Comprehensive Cancer Network (NCCN) recently released updated Genetic/Familial High-Risk Assessment: Breast, Ovarian, Pancreatic, and Prostate Cancer guidelines (Version 1.2026), which included updates to CHEK2 content. To learn more, check out the full guidelines by creating a FREE account at: https://www.nccn.org/professionals/physician_gls/pdf/genetics_bopp.pdf
Permanent link to this article: https://inheritedcancer.net/post080825/
ICARE Social Media Post June 2025 2025
PREMM5: Model to Estimate the Risk for Having Lynch Syndrome
ICARE Social Media Post June 2025 2025
PREMM5: Model to Estimate the Risk for Having Lynch Syndrome
PREMM5 is a model to estimate the risk for having Lynch Syndrome. PREMMplus is a model that estimates risks in 19-cancer risk genes, including Lynch Syndrome genes, BRCA, and other genes. A new study that compared PREMM5 and PREMMplus found that PREMMplus was just as good as PREMM5 in identifying patients with Lynch Syndrome. PREMMplus …
Permanent link to this article: https://inheritedcancer.net/post060325/
ICARE Social Media Post May 2025
Familial Adenomatous Polyposis (FAP): Risk-Reducing Colectomy
ICARE Social Media Post May 2025
Familial Adenomatous Polyposis (FAP): Risk-Reducing Colectomy
A new study among patients with Familial Adenomatous Polyposis (FAP), most of whom had a their colon removed to prevent cancer, found that although risk-reducing colectomy is now standard practice in FAP patients, colorectal cancer remains the most common cancer and cause of death in these patients. Recognizing cases of FAP that are ‘de novo’ …
Permanent link to this article: https://inheritedcancer.net/post52725/
ICARE Social Media Post July 2024
Genetics Role in Identifying Lower Breast Cancer Risk
ICARE Social Media Post July 2024
Genetics Role in Identifying Lower Breast Cancer Risk
A new study of 25,591 women found: Based on genetic risk, identifying individuals at: This study challenges a one-size-fits all mammogram screening approach. This approach could possibly reduce rising healthcare costs by reallocating resources and lower unnecessary anxiety that comes with frequent screenings, and even prevent unnecessary procedures. Read the full article to learn more …
Permanent link to this article: https://inheritedcancer.net/post72924/
ICARE Social Media Post March 2024
Risk Management Strategies for Women with BRCA1/2
ICARE Social Media Post March 2024
Risk Management Strategies for Women with BRCA1/2
Two new research studies that 𝗶𝗻𝗰𝗹𝘂𝗱𝗲𝗱 𝗜𝗖𝗔𝗥𝗘 𝗽𝗮𝗿𝘁𝗶𝗰𝗶𝗽𝗮𝗻𝘁𝘀 showed that risk of death is lowered among BRCA1/2 carriers with 1) MRI screening for breast cancer and 2) removal of both ovaries and fallopian tubes. 💡 In the first study, MRI screening greatly lowered the risk of death from breast cancer (hazard ratio of 0.23) with …
Permanent link to this article: https://inheritedcancer.net/post3524/
Permanent link to this article: https://inheritedcancer.net/1nlw2021/
ICARE Social Media Post February 2020
Ovarian Cancer Risks in BRCA1/2
ICARE Social Media Post February 2020
Ovarian Cancer Risks in BRCA1/2
The risk of ovarian cancer is raised in women with BRCA1/2 mutations. Recent findings suggest that higher body mass index (BMI) may further raise the risk of ovarian cancer in premenopausal BRCA1/2 carriers. Note that all women with BRCA1/2 mutations are at high risk for ovarian cancer, and should follow current National Comprehensive Cancer Network …
Permanent link to this article: https://inheritedcancer.net/post21820/
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